Interleukin-17 and its expanding biological functions
نویسندگان
چکیده
منابع مشابه
Regulating Maf1 Expression and Its Expanding Biological Functions
Maf1 is a nutrientand stress-sensitive global repressor of transcription by RNA polymerase (pol) III [1,2]. Its primary function in this context is to limit the synthesis of highly abundant 5S rRNA and tRNAs in response to nutrient availability and cellular stress [3]. Thus, Maf1 ensures the efficient use of metabolic resources while balancing the need for protein synthetic components during ce...
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Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additional members have been identified and cloned: IL-17B, IL-17C, IL-17D, IL-17E a...
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Background: Inflammatory bowel disease, an autoimmune disease, has two clinical manifestations including Crohn’s disease and ulcerative colitis (UC). IL-17 has been the target of intensive research in autoimmune diseases. The influence of Toll like receptor 4 (TLR-4) gene polymorphisms on IL-17 production has also been revealed in UC patients and tissue inflammation in mice. Objectives: To inve...
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Institute for Molecular Bioscience, University of Queensland, Queensland Bioscience Precinct, Brisbane, QLD 4072, Australia, Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom, and Photon Science, SLAC and Structural Biology, School of Medicine, Stanford University, 2575 Sand Hi...
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ژورنال
عنوان ژورنال: Cellular & Molecular Immunology
سال: 2010
ISSN: 1672-7681,2042-0226
DOI: 10.1038/cmi.2010.21